Housepets! 主要背景設定在美國境內某郊區，名為巴比倫花園（Babylon Gardens）的地方（故事沒有明確指出位置，但作者表示主角家的設定是建立在他過去北卡羅來納州的居所）。這部作品的時空當中，大部分動物都具有理智情感，且大多高度擬人化，能夠行走、談話、與現實動物相比來得長壽。動物也享有部分的人類權利（例如警犬有資格逮捕人類），不過野生動物若沒有被收養為寵物則不具法定地位（有個特例，收養人允許是寵物本身)。漫畫主焦點放在兩個角色身上：Sandwich（三明治）家族的 Peanut Butte
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